Enalapril EP Impurity A(HCl) CAS 76420-74-1 (free base)
| CAS No. | 76420-74-1 (free base) |
| Molecular Formula | C20H28N2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Enalapril EP Impurity A(HCl) (C20H28N2O5HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Enalapril EP Impurity A(HCl) (CAS 76420-74-1 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C20H28N2O5HCl and a molecular weight of 412.91 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Enalapril EP Impurity A(HCl) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H28N2O5 HCl |
| Molecular Weight | 412.91 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Enalapril Standards
- Enalapril tert-Butyl Ester (CAS 108428-39-3)
- Enalapril Maleate Impurity 26 (CAS 115623-21-7)
- Enalapril EP Impurity D (CAS 115729-52-7)
- Enalapril-d5 tert-Butyl Ester (CAS 1356837-84-7)
- Enalapril-d3DISCONTINUED. Please see E555258 and E555252 (CAS 1356847-94-3)
- Enalapril EP Impurity A Maleate (CAS 1356932-13-2)
- Enalapril Impurity 19 (CAS 15121-89-8)
- Enalapril Impurity N1 (CAS 17450-56-5)
Recommended Standards
- Dacomitinib Impurity 37 (CAS CATO-C4X-208637)
- Isoprenaline Impurity 43 (CAS CATO-C4X-277543)
- Phenylbutazone EP Impurity A (CAS 3583-64-0)
- tert-Butyl 4-(4-ethoxy-4-oxobutyl)piperidine-1-carboxylate (CAS 142247-37-8)
- 2,5,7-Triazaspiro[3.4]octane-6,8-dione (CAS 1026796-16-6)
- 5-Amino-2-chloro-N-(4-propoxyphenyl)benzamide (CAS 1455622-52-2)
- N-(3-Phenylpropyl)-4-(pyridin-2-yloxy)piperidine-1-carboxamide (CAS 1421513-01-0)
- 2-(1-Phenylethyl)-2,3-dihydroisothiazole 1,1-dioxide (CAS 1373028-76-2)
- 4-[(2,6-Dichlorophenyl)imino]tetrahydro-3-thiophenecarboxylic Acid Methyl Ester (CAS 126856-32-4)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
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